Rat Anti-Mouse F4/80 mAb (AF488)

FC-5μL per test for million cells or whole blood in 100 μL volume.

Rat

AF488. Ex:490nm.Em:525nm.

Unmodified

13733

Mouse F4/80

IgG2b

Monoclonal Antibody

CI:A3-1

A synthesized peptide derived from Mouse F4/80

Immunology

F4/80 is a 160 kD glycoprotein. It is characterized as a member of the epidermal growth factor (EGF)-transmembrane 7 (TM7) family. F4/80, also known as EMR1 or Ly71, has been widely used as a murine macrophage marker, which is expressed on the majority of tissue macrophages including peritoneal macrophages, macrophages in lung, gut, thymus and red pulp of spleen (but not on the macrophages located in T cell areas of the spleen, lymph node and Peyer's patch), Kuffer cells, Langerhans cells, and bone marrow stromal cells. F4/80 has also been shown on a subset of dendritic cells. The biological ligand of F4/80 has not been identified, but it has been reported that F4/80 is required for induction of CD8+ T cells-mediated peripheral tolerance.

Affinity Purified

Liquid

Liquid in PBS with 0.05% Proclin300, 1% BSA

Store at 2-8°C..Avoid light.Avoid freeze/thaw cycles.